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We have no deal with Pfizer to manufacture their vaccine.Something I'm really not understanding about this whole vaccine rollout but hopefully someone can explain.
We seem to be using two vaccines in Australia, one made by Pfizer and the other by Astra Zeneca.
The AZ vaccine reportedly has a 63% effectiveness: https://www.who.int/news-room/featu...zeneca-covid-19-vaccine-what-you-need-to-know
The Pfizer vaccine is reported to be 95% effective: https://www.yalemedicine.org/news/covid-19-vaccine-comparison.
The AZ vaccine comes with a small but not zero chance of blood clots, the occurrence of which has resulted in actual deaths. The Pfizer vaccine does not come with this problem.
So if one is 63% effectiveness with a small but not zero chance of really bad side effects, and the other is 95% effective without that risk, then why on earth is anyone using the less effective and more dangerous one?
What am I missing here? Shouldn't all focus be on the one that's more effective and safer?
Something I'm really not understanding about this whole vaccine rollout but hopefully someone can explain.
We seem to be using two vaccines in Australia, one made by Pfizer and the other by Astra Zeneca.
The AZ vaccine reportedly has a 63% effectiveness: https://www.who.int/news-room/featu...zeneca-covid-19-vaccine-what-you-need-to-know
The Pfizer vaccine is reported to be 95% effective: https://www.yalemedicine.org/news/covid-19-vaccine-comparison.
The AZ vaccine comes with a small but not zero chance of blood clots, the occurrence of which has resulted in actual deaths. The Pfizer vaccine does not come with this problem.
So if one is 63% effectiveness with a small but not zero chance of really bad side effects, and the other is 95% effective without that risk, then why on earth is anyone using the less effective and more dangerous one?
What am I missing here? Shouldn't all focus be on the one that's more effective and safer?
Something I'm really not understanding about this whole vaccine rollout but hopefully someone can explain.
We seem to be using two vaccines in Australia, one made by Pfizer and the other by Astra Zeneca.
The AZ vaccine reportedly has a 63% effectiveness: https://www.who.int/news-room/featu...zeneca-covid-19-vaccine-what-you-need-to-know
The Pfizer vaccine is reported to be 95% effective: https://www.yalemedicine.org/news/covid-19-vaccine-comparison.
The AZ vaccine comes with a small but not zero chance of blood clots, the occurrence of which has resulted in actual deaths. The Pfizer vaccine does not come with this problem.
So if one is 63% effectiveness with a small but not zero chance of really bad side effects, and the other is 95% effective without that risk, then why on earth is anyone using the less effective and more dangerous one?
What am I missing here? Shouldn't all focus be on the one that's more effective and safer?
Also from my understanding the AZ vaccine can be made here.Nothing, at the start of the COVID vaccine development Australian experts were crying out for the Government to fund mRNA production here in Australia.
The governments response was it would take a year to setup, this was Feb 2020.
Instead they went all in with AZ.
I imagine this was based on advice heaven forbid if it wasn't at that time there had been no successful mRNA vaccine produced..
Problem now is we are in a very long line looking for supply from Pfizer.
Down the road our bigger problem will be possibly getting caught out with a population not vaccinated and a nasty variant breaking out.
The government know there is a train coming at them as the delay in opening international boarder will have major ramifications politically hence the jumping in behind the states.
Phizer is looking like the safest long term bet, but long term means different things to a 30 year old , than a 75 year old.3 doses, then 1 each year: why Pfizer, not AstraZeneca, is the best bet for the long haul
Our best long-term strategy is to rely on the mRNA vaccines like Pfizer and Moderna.theconversation.com
Would you hold off for this?
My thinking too. From what I know, one can change to Pfizer for future injections (booster, not the 2nd injection) and hopefully it will be readily available at year end.Phizer is looking like the safest long term bet, but long term means different things to a 30 year old , than a 75 year old.
The other aspect is, I would have thought just because someone has the AZ shot this year, which covers the current virus, shouldn't preclude the same person having the Phizer MRNA vaccine next year when it becomes more available.
“Any vaccine trial should include regular antigen testing every three days to test contagiousness to pick up early signs of infection and PCR testing once a week to confirm infection by SARS-CoV-2 test the ability of the vaccines to stave off infection. Prevention of infection is not a criterion for success for any of these vaccines.
He also explains that while most people expect that a vaccine will prevent serious illness in the event they’re infected, “Three of the vaccine protocols — Moderna, Pfizer, and AstraZeneca — do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache.”15In fact, their endpoints all require confirmed infections and all those they will include in the analysis for success, the only difference being the severity of symptoms between the vaccinated and unvaccinated. Measuring differences amongst only those infected by SARS-CoV-2 underscores the implicit conclusion that the vaccines are not expected to prevent infection, only modify symptoms of those infected.”
I explained some aspects of this earlier.I was surprised to find that 'effectiveness' was only a reduction of symptoms after you got the virus. This came out in Nov 2020
COVID-19 Vaccine Trials ‘Designed to Succeed’
In September 2020, Haseltine criticized COVID-19 vaccine trials, including Pfizer’s, saying their protocols reveal that they’re “designed to prove their vaccines work, even if the measured effects are minimal.”13
He points out that prevention of infection is a critical endpoint in a normal vaccine trial, but prevention of infection is not a criterion for success for COVID-19 vaccines in development by Pfizer, Moderna, AstraZeneca or Johnson & Johnson. According to Haseltine:14
He also explains that while most people expect that a vaccine will prevent serious illness in the event they’re infected, “Three of the vaccine protocols — Moderna, Pfizer, and AstraZeneca — do not require that their vaccine prevent serious disease only that they prevent moderate symptoms which may be as mild as cough, or headache.”15
My thinking too. From what I know, one can change to Pfizer for future injections (booster, not the 2nd injection) and hopefully it will be readily available at year end.
But there is no point in dying waiting for it, when there is a readily available but maybe not as effective vaccine available.
One thing I am not sure of and perhaps someone can enlighten me. The vaccines can not only prevent catching COVID-19, but also reduce the symptoms enormously if one does catch COVID-19. For example, many do not even require hospitalisation. Although AZ does not work against catching some strains of the virus, in the event that one does catch those strains, will it have the same mitigating effect on the symptoms?
My thinking too. From what I know, one can change to Pfizer for future injections (booster, not the 2nd injection) and hopefully it will be readily available at year end.
But there is no point in dying waiting for it, when there is a readily available but maybe not as effective vaccine available.
One thing I am not sure of and perhaps someone can enlighten me. The vaccines can not only prevent catching COVID-19, but also reduce the symptoms enormously if one does catch COVID-19. For example, many do not even require hospitalisation. Although AZ does not work against catching some strains of the virus, in the event that one does catch those strains, will it have the same mitigating effect on the symptoms?
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