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Surrounding circumstances and a sense of justice plays a big role there too.
A loss due to natural or otherwise unavoidable circumstances is one thing.
Being a victim of some sort of injustice, either perceived or real, is entirely different and especially so if whatever is lost is something that matters.
If there's injustice, then there's a desire for justice or retribution. If there's something lost, then there's a desire for its return. Every single human problem can be defined in terms of thwarted desire or more specifically, the clinging/yearning it tends to create. Why define human suffering in terms of clinging/yearning? Because a precise definition of suffering allows the possibility of a solution.
Clinging/wanting/yearning is what creates anxiety, and anxiety is what creates depression. Both are suffering. It doesn't matter if you yearn for world peace, the well being of others of a huge pile of cash - it's all suffering and all feels the same. It's damaging.
There's only two approaches - 1] get what you want (or at least enough to maintain your chemical balance of neurotransmitters), or 2] do something to the mind to prevent clinging/yearning. The second option generally involves spiritual techniques which I don't think anyone is interested in. Sometimes it can be achieved with distraction, but that's always problematic. There's nothing new in any of this, but clarity is essential. No topic is more important to understand than human suffering because it happens to everyone to some degree or other.
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