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Good international stocks to buy



Boeing (likely) bailout. TBTF




This is the lesson from LEH. Do not allow pivotal firms to fail. Not saying it's right, just the lesson learned from 2008.

jog on
duc
 
Tiziana Lifesciences Develops Novel Investigational Treatment For Patients Infected with COVID-19 Utilizing Direct Delivery of Anti-Interlukin-6-Receptor Monoclonal Antibodies

https://www.gurufocus.com/news/1100...antiinterlukin6receptor-monoclonal-antibodies

NEW YORK and LONDON, April 09, 2020 (GLOBE NEWSWIRE) -- Tiziana Life Sciences plc ( NASDAQ:TLSA) (“Tiziana” or the “Company”), a biotechnology company focused on innovative therapeutics for inflammatory and autoimmune diseases, announced today that it has developed investigational new technology to treat COVID-19 infections, which consists of direct delivery of anti-IL-6 receptor (anti-IL-6R) monoclonal antibodies (mAbs) into the lungs using a handheld inhaler or nebulizer. Development of this novel technology is a step forward toward expediting development of TZLS-501, a fully-human anti-interleukin-6 receptor (anti-IL6R) monoclonal antibody (mAb) for treatment of patients infected with COVID-19 (SARS-CoV-2) coronavirus. The Company believes the technology could also be applicable for use with other FDA approved mAbs and drugs. The Company has submitted a provisional patent application for the delivery technology.
 
@noirua , you have been pushing NASDAQ:TLSA for a while.What is your reasoning? Are you involved in that research?
From an external point of view, i i s the link between the virus and their work as just at best fortious.they were not working on this type of illness were they? I am no expert and maybe it could help, as an old antimalarial compounds does..sheer luck
Anyway, interested to know the reasons behind your support
 
The thread is "Good International Stocks to Buy". Do your own research as the share is highly volatile and particularly so in Pre-Market and After-Market trading. Intra-day on Thursday the shares rose over 100% in the states

Preventing COVID-19-induced pneumonia with anticytokine therapy
https://www.thelancet.com/journals/lanrhe/article/PIIS2665-9913(20)30092-8/fulltext

Potential strategies using anti-IL-6 therapies have not been as widely tested as in the case of TNF-a or IL-1. Tocilizumab is a monoclonal antibody that blocks both membrane-bound and circulating IL-6 receptor.
Randomized trials in patients with rheumatoid arthritis have shown that tocilizumab increases total, HDL, and LDL cholesterol and triglyceride levels [144].
Moreover, it results in improved endothelial function and decreased aortic stiffness [145].
Currently, several ongoing studies investigate the role of tocilizumabin in NSEMI (Phase 2 trial) and in comparison to etanercept in patients with rheumatoid arthritis and cardiovascular risk factors (Phase 4 trial).

Several major therapies are effective for RA, namely, biologic antiinflammatory drugs, e.g., anti-TNF, anti-IL-6, and anti-CD20.35
The development of anti-TNF therapy in particular changed RA therapy completely and triggered the development of other biologic antiinflammatory drugs now used for RA.
However, although approximately 50% of patients benefit from anti-TNF therapy, 30% of patients still do not respond and 20% of patients only weakly respond to the therapy.35 Interestingly, treating anti-TNF nonresponding patients with other biologic drugs was not effective.35
Also combining anti-TNF with other immune-modulatory drugs such as anti-IL-1 (anakinra) or CTL4-Ig (abatacept) increased the incidence of infection without much benefit.35-37 Recently, it was discovered that anti-TNF induces Th17 expansion, resulting in higher levels of IL-17 production.
This was shown in both human RA patients38 and mouse model of arthritis,39 and the outcome of the therapy in human RA inversely correlated with the level of IL-17.38 TNF downregulates myeloid cell expression of IL-23, and blocking TNF is thought to induce IL-23 production, resulting in the expansion of Th17 cells.39
Anti-IL-17 therapies are in phase III clinical trial for RA, and it was so far shown that anti-IL-17 efficacy is not as good as anti-TNF.40
There is a potential opportunity to coadminister anti-TNF and anti-IL-17, which is effective in CIA in mice.38
However, this may increase a risk of infection as described earlier. Therefore, it may be ideal to coadminister a drug that targets nonimmune process in combination with anti-TNF, such as an anti-MP drug.
https://www.sciencedirect.com/topics/neuroscience/anti-il-6
 
Mining share tips: a big one and five small ones
29th June 2022 13:10
Https://www.ii.co.uk/analysis-commentary/mining-share-tips-big-one-and-five-small-ones-ii524513?utm_source=newsletter%20&utm_medium=email&utm_campaign=NEW-WKLY-ENGAGE-weekend_round_up_020722&utm_content=newsletter%20&spMailingID=20065198&spUserID=ODIzODEzNDUxMzE0S0&spJobID=2030314564&spReportId=MjAzMDMxNDU2NAS2
Alongside iron ore, nickel is out of favour as stainless steel mills destock and lithium is also shunned due to the prospect of more supply on the back of last year’s price spike.​
 
Current Oil trend is down though, I think the Oil stock money is already made in the last few months...



But there might be another opportunity brewing in the Energy sector. Given that Europe is going into winter and will need gas for heating, yet they are at the mercy of Putin cutting off the Russian gas pipeline. So, I hypothesise that Gas and LNG stocks may continue to do well, and Natural Gas prices are staying elevated...


So if we find the right Gas/LNG stocks, we may be able to have a speculation. Could be international stocks or even local gas/LNG stocks perhaps ?
 
My view is i do not see oil go down that much if gas coal stays that high: power plant will burn oil...people kerosene in tgeir frozen german flats etc.
Energy is energy, and when needs come, switch and tech change can be expedited.
During WWII, cars trucks etc when from oil to wood generated gas in a year....and logistics and infrastructure were not as good as they are now, even with sneezing workforce...
So whole sector is green.
I personally went wds here but keen on OS gas player too..maybe eft?
 

Investing in oil is for the brave and those in the know, volatility may create opportunity and heartbreak.

LNG consumption has increased as countries move away from oil, but supply is tight. This causes governments and industry to innovate and create solutions.

Current data indicates that oil production is increasing and consumption is decreasing.

Two of the biggest consumers USA and India have recorded a decrease in demand for the black gold, this has occurred while Russia cuts supply, world economic downturn, and new energy sources increasing over the past decade due to environmental and security reasons.


 

@JohnDe and all who see the three stocks that I like, I should have made it clear that I'm not looking at these from an investing standpoint, only for trading. The markets at the moment are very volatile and even if you are trading in this environment you would need to be very tactical, i.e. short term trading. I don't recommend that anyone trades these stocks unless you do your own research on them and they get the tick from your own trade plan, personally I think that they are worth looking at.
 
Besides short term trading (which you have already said is your focus with these stocks), I think there is still a lot of good money to be made in e oil and gas industry, but of course it’s a volatile business, so I think it is definitely going to become the realm of the long term investors.

I think this is how Warren Buffett is looking at it, he has been buying up a lot of oil investments, but his company is patient enough to ride through the ups and downs, and I think his is confident that even though in the super long term it’s an industry that will decline, over that time given the annuity style investment of each oil project that the dividends over the years will be worth it.

He is also leaning more to the businesses that control refining and chemical infrastructure, not just pure oil and gas production, these businesses have the unique chemistry and infrastructure skill sets that may give them an edge in the transition to hydrogen based synthetic fuels for planes and ships and the chemical industry feedstocks.

So yeah, I think when it comes to this industry it’s either short term trading, or super long term holders that will do the best.
 
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