It only runs on Windows and Iress should be running and logged in. Because it's in PyPI you can install it quickly using either easy_install or pip. You'll also need the Python win32 extensions installed so you can dispatch to the Iress COM interface.
The Iress DataManager interface allows you to programmatically extract all the data that's presented through the user interface. I've found the ability to query data and insert it into a Postgres database hugely useful in my research.
The following example shows how you can pull out all the financials (EBITDA, NAV, etc) for BHP during 2008 using the pyress library.